Global DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function

Global DNA methylation remodeling accompanies CD8 T cell effector function.

The differentiation of CD8 T cells in response to acute infection results in the acquisition of hallmark phenotypic effector functions; however, the epigenetic mechanisms that program this differentiation process on a genome-wide scale are largely unknown. In this article, we report the DNA methylomes of Ag-specific naive and day-8 effector CD8 T cells following acute lymphocytic choriomeningit...

DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.

Transcriptional silencing mediated by DNA methylation is a critical component of epigenetic regulation during early embryonic development in animals. However, the requirement for DNA methylation during activation and differentiation of mature CD8+ T cells into effector and memory cells is not clear. Using cre-mediated deletion of DNA methyltransferase 1 (Dnmt1) at the time of CD8+ T cell activa...

Prolonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development.

After priming, naive T cells undergo a program of expansion, contraction, and memory formation. Numerous studies have indicated that only a brief period of antigenic stimulation is required to fully commit CD8+ T cells to this program. Nonetheless, the persistence of Ag may modulate the eventual fate of CD8+ T cells. Using DNA delivery, we showed previously that direct presentation primes high ...

Notch controls effector CD8+ T cell differentiation

CD8+ T cell recognition of foreign antigen induces the expansion of the few T cells bearing an appropriate T cell receptor and the acquisition of effector functions. These effector CD8+ T (Te) cells eliminate the pathogen by secretion of cytokines or by direct cytotoxicity. Following this initial clonal expansion, 90-95% of the Te cells die while the few others further differentiate into memory...

Self-Antigen Prevents CD8 T Cell Effector